The majority of spatial learning and memory studies over the past four decades have used the morris water maze, but there are many shortcomings to and challenges in using this traditional. All the place cell analyses, except spatial coherence, were done on 1d place fields. Cognitiveenhancing and antioxidant activities of the. Rats performed in an eightarm radial maze in which choosing each arm without repetition was the optimal behavior. Animal behavior, data analysis, experimental psychology, laboratory experiments, memory, psychological studies, rats, research. In a freechoice procedure, rats showed an increased tendency to choose the location that had most recently been chosen by a foraging partner but a decreased. Therefore, we developed a simple and novel task to examine rats ability to demonstrate memory for objects, their spatial position, and the context in which they appeared. Development of the spatial representation system in the rat. We predicted that promiscuous male giant pandas would make fewer errors than females on a spatial memory task, but there would be no sex differences in the performance of monogamous asian smallclawed otters. Dissociation of spatial reference memory, spatial working memory, and hippocampal mossy fiber distribution in two rat strains differing in emotionality. Exploring the limits of spatial memory in rats, using very. The predictive value of the spatial and memory descriptions were evaluated by testing rats with damage to the hippocampal system in a series of experiments, independently.
The role of the hippocampus in learning and memory essaysthe role of the hippocampus in learning and memory has been examined for many years. Foraging for food, returning to sites of storage or safety, and avoiding sites of danger within a complex and changing environment present a daily challenge to. After one rat observer was put in the centre room, another rat demonstrator was trained to find food pellets in the maze. A novel open field activity detector to determine spatial. To obtain reinforcement, ss were required to press 2 keys 4 times each, in any order. In conclusion, spatial memory in rats lasts at least 25 hr. Investigates memory capacity in rats for information about spatial location and provides information about some of the characteristics of the storage process used in this memory. Spatial memory in rats after 25 hours pubmed central pmc. There is little question that the hippocampus plays a role in many non spatial processes 1214. Treatments that interfere with animals shortterm retention e. To determine whether working memory wm and reference memory rm represent different aspects of spatial memory, albino wag rats and the pigmented brown norway rats were tested in the acquisition, retention, and reversal of spatial orientation tasks in the holeboard, which allows the simultaneous assessment of wm and rm. These findings agree with jacobss 1992 and jacobs and limans 1991 experiments showing spatial memory for hoarded food in squirrels and kangaroo rats and provide a model for studying this phenomenon in laboratory. In cognitive psychology and neuroscience, spatial memory is a form of memory responsible for the recording of information about ones environment and spatial orientation.
These 1d place fields were obtained by using 2 cm bins on linear track, and these raw place fields were smoothed by applying a gaussian smoother with a 2. Memory enhancing activities of the aqueous extract of albizia adianthifolia leaves in the 6hydroxydopaminelesion rodent model of parkinsons disease. Exp i showed that ss developed stereotyped response sequences even when the reinforcement contingency did not require stereotypy. In rodents, working memory is a representation of an object, stimulus, or spatial location that is typically used within a testing session, but not between sessions, to guide behaviour. Citeseerx document details isaac councill, lee giles, pradeep teregowda. Assessing spatial learning and memory in rodents ilar. Background and purpose hepatic encephalopathy is a neuropsychiatric disorder of complex pathogenesis caused by acute or chronic liver failure.
The radial arm maze was designed by olton and samuelson in 1976 to measure spatial learning and memory in rats. Plants of the genus markhamia have been traditionally used by different tribes in various parts of west african countries, including cameroun. To the extent that spatial location cues direct choice behavior, the rats should go to the unchosen spatial location. Place field size was calculated as the number of 2cmwide bins above 1 hz threshold. Hippocampus, space, and memory behavioral and brain. Alzheimers disease ad could be considered a multifactorial neurodegenerative disorder characterized by the accumulation of the. Learning of efficient behaviour in spatial exploration. M ale mice exhibit better spatial working and reference memory than. Bignoniaceae is used as an antimalarial, antiinflammatory, analgesic, antioxidant and antialzheimer agent. Rats performed in an eightarm radial maze in which. The first three experiments demonstrated that the animals performed efficiently, choosing an average of more than seven different arms within the first eight choices, and did.
Adapted from figure 2, remembrance of places you passed. Rats were tested on an eightarm maze in a paradigm of sampling with replacement from a known set of items until the entire set was sampled. An overview of the tasks used to test working memory in. If the item delivery occurred in or near a cells place field, characterized by a firing rate that is significantly higher than the baseline level, then. Because the test measures trialdependent memory, it is an assessment of working memory and, more specifically, spatial working memory because the principal cues to guide arm choices are outside the maze.
Is the concept applicable to the analysis of memorial struggles. Neural activity in human hippocampal formation reveals the. Moreover, increasing the spacing of trials is an effective method to increase spatial memory. Research over the past thirty years has confirmed that the rat hippocampus has an important role in spatial memory and navigation. Spatial memory is highly relevant in biology because it is related with both individual and species survival. Investigates memory capacity in rats for information about spatial.
Hippocampal and neocortical interactions during context. These studies suggest that rats process information with multiple, independent working memory systems for olfactory and spatial information. The radial arm maze ram for the evaluation of working. The role of the hippocampus in learning and memory essays. The original apparatus consists of eight equidistantly spaced arms, each about 4 feet long, and all radiating from a small circular central platform later versions have used as few as three. Cognitive representations of spatial location kate j. Among behavioural tests, one of the most suitable devices for measuring spatial learning and memory is the radial arm maze ram 1,2. Wilson1 the hippocampus has long been known to be involved in spatial navigational learning in rodents1,2, and in memory for events in rodents3,4, primates5 and humans6. Improved working memory following novel combinations of physical and cognitive activity.
These data were discussed in terms of the fundamental problems posed by variations in the number of food locations in the pursuit of the limit of spatial memory in rats. The problem is that animals may solve the maze in ways other than relying on spatial working memory. Proactive inhibition and patterns of choice in rat spatial memory. For example, a persons spatial memory is required in order to navigate around a familiar city, just as a rats spatial memory is needed to learn the location of food at the end of a maze. Cognitive impairment in a young marmoset reveals lateral ventriculomegaly and a mild hippocampal atrophy. A unifying property of both navigation and event memory is a requirement for dealing with. Improved working memory following novel combinations of. The traditional eight radial arm maze has many variants that allow mice, rats, and even primates to display their spatial working memory for the arms that they have visited by avoiding reentry. Ht 1a, on brain and liver functions in a model of hepatic. When distinctive exteroceptive discriminative stimuli are consistently associated with a particular spatial location, rats preferentially use these stimuli for discrimination learning, a phenomenon that is usually referred to as place learning. Spatial memory in rats 99 form to the end of an arm and back again. Spatial memory for food hidden by rats rattus norvegicus. Performances were interrupted between fourth and fifth choices for a delay of 15 sec to 2 min.
Odor and other physical traces of the other rat s visits were ruled out as explanations for this effect. Pairs of rats were tested in a radialarm maze to determine whether the spatial choices made by one rat affect the subsequent spatial choices of the other rat. The present work was carried out to investigate the neuroprotective effect of cis carveol 1% and 3%, for 21 days against. If place learning can be used to solve a discrimination problem, rats. Spatial memory in the rat on a hierarchical maze sciencedirect. Seven experiments examined the effects of contingent reinforcement on complex responses in 115 undergraduates.
Social influences on rat spatial choice comparative cognition. The sensory basis of spatial memory in the rat springerlink. The current study was undertaken in order to investigate its antiamnesic and antioxidant. The first three experiments demonstrated that the animals performed efficiently, choosing an average of more than seven different arms within the first eight choices, and did not utilize intramaze cues or consistent chains of responses in solving the task. Rudiments of place cells, head direction cells, and grid cells already existed when the pups made their first movements out of the nest. Download pdf open epub full article content list abstract. This is a pdf file of an unedited manuscript that has. Norway rats have been shown to depend on shortterm spatial memory to find food on a radial arm maze ram, but what locomotor search tactics are involved in using this memory effectively. Whishaw and maaswinkel pretrained both fornix lesioned rats and control rats to leave a homecage, wander out into a simulated test environment and retrieve food, and then return the food to their homecage. This evidence leads to the conclusion that rats used spatial memory to locate hidden food in the retrieval phase of each trial. Studies have used rats, monkeys, and other animals and given them a variety of lesions to the hippocampus and other parts of the brain. How is radial arm maze behavior in rats related to.
We investigated the time course of spatialmemory decay in rats using an eight arm. We investigated the time course of spatialmemory decay in rats using an eightarm. Four experiments distinguished tactics of distance minimizing, central place search, trail following, thig. We prepared a closed observation room in the centre of the maze. The results are discussed in terms of the memory processes involved in this task and human serial learning. For the first half of last century, behavioural neuroscience was dominated by associative explanations of learning and memory. Spatial memory supports retrieval of the locations of objects and places in the environment, an essential aspect of behavior in humans and other mobile animals. Samuelson the johns hopkins university rats were tested on an eightarm maze in a paradigm of sampling with. The percentage of novel choices appeared to be determined more by spatial proximity than by number of arms. Thus, recalling an episodic memory involves recovery of its spatial context, as seen in the activity of place responsive cells in the human hippocampal formation and surrounding mtl regions. Read a novel open field activity detector to determine spatial and temporal movement of laboratory animals after injury and disease, journal of neuroscience methods on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at.
Social spatial working memory in rats article pdf available in journal of experimental psychology animal behavior processes 333. To the extent that arm cues such as odor trail direct choice behavior, the rats should go to the unchosen arm while repeating their choice of spatial location. Effects of inescapable shock on subsequent escape and avoidance learning. Memoryenhancing activities of the aqueous extract of. Typically, they do so by relying on their memory for the spatial location of visited arms relative to extramaze landmarks in the testing environment.
Cannabidiol improves brain and liver function in a. Under some conditions, locations were chosen later in the choice sequence of a subject rat if another rat had been observed choosing that location. The other emphasizes memory, particularly working memory, a shortterm memory that requires iexible stimulusresponse associations and is highly susceptible to interference. Such radial mazes are based on natural foraging activities of rats and used to measure their spatial memory. In experiment 2, rats foraged for food in four successive phases with 8, 16, 24, and 48 arms attached to the maze in spreadout or. For 5 d, rats on the ketone diet ran 32% further on a treadmill than did control rats that ate an isocaloric diet that was supplemented with either corn starch or palm oil p rats completed an 8arm radial maze test 38% faster than did those on the other diets, making more correct decisions before making a mistake p memory provides a possible model of episodic memory for use with nonhuman animals, it involves lengthy pretraining to demonstrate memory in both rats and monkeys. Available formats pdf please select a format to send.
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